This page, and the others listed in the left sidebar may have some good ideas for you...
http://us2.php.net/manual/en/book.apc.phpSome of my colleagues have spoken well of memcacheD:
http://us2.php.net/manual/en/book.memcached.phpFinally, not to badmouth frameworks, but you might want to look at your page load time for the Hello World script. I have found that some frameworks dynamically load numerous little pieces - separate classes in separate files, and so on - that the page load time for even the simplest pages is greatly influenced by the disk service time required to gather up all those little files. If there is a way to combine the files so that the framework loads fewer files as it services each HTTP request, that is almost certain to help performance across the site.
Hope that helps, ~Ray