Get Process Explorer from Microsoft and see exactly which application is sending the email out.
http://download.sysinternals.com/Files/ProcessExplorer.zip
Kill the application, scan the system and clean it.
You could also try HitManPro
32bit
http://dl.surfright.nl/HitmanPro35.exe
64bit
http://dl.surfright.nl/HitmanPro35_x64.exe
Sudeep