There actually is a Microsoft Knowledge Base Article, that addressess this
Here is the core part
These symptoms are most noticeable during mail delivery or during synchronization. These symptoms become more pronounced as store size increases. They are more likely to occur when the size of the .pst file or the size of the .ost file approaches 2 gigabytes (GB). Additionally, they are more pronounced in a very large .pst file or in a very large .ost file that is 4 GB or larger.
If you use a portable computer If you are using a portable computer, you may experience these problems sooner than you would on a desktop computer. This occurs because hard disks on portable computers are generally slower than hard disks on desktop computers. The performance problems are directly related to hard disk speed. If you add more random access memory (RAM) to a computer, there is no effect on this problem.
There is an update mentioned in the KB that may help slightly
Here's the link to the KB
http://support.microsoft.com/kb/932086