1) List the numbers 1 through 50 in A1:A50
2) Put the following formula in cells B1:B50
=RAND()
3) To pull a set of umpteen unique random numbers, use the following formula in cell C1 then copy it down:
=INDEX($A$1:$A$50,MATCH(SMALL($B$1:$B$50,ROWS($C$1:$C1)),$B$1:$B$50,0))
Each time you hit F9, you get a different selection of random numbers
For grins, the sample workbook highlights any duplicates.
Brad