The setting is stored in the registry on each machine. You could create a script which turns it off on log on.
Something like this may work:
Login Script
Internet Explorer stores proxy settings in the registry. Using the login script to update client registries makes it easy to update. Even if your users do not normally use Internet Explorer as their usual browser, you will want to configure the proxy settings because many other applications key off proxy settings in Internet Explorer.
In the example shown below, you determine the proper proxy IP and Port for users, export the settings to a .REG file, and then use REGEDIT in the login script to push the settings to the PC.
Note: If you leave the setting in the login script for several days, most of the PC's should be updated by then, and you can remove or comment out the commands.
Please use caution in making changes to the registry. If you are not comfortable with these changes or do not fully understand what these changes will do, please obtain assistance from someone who is comfortable with the Windows registry.
Create setproxy.reg (any filename can be used)
Open notepad & type in as follows:
Windows Registry Editor Version 5.00 (or the appropriate version of regedit, if different)
[HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Internet Settings] "ProxyServer"="<Your Proxy IP Address>:<Proxy Port>" "ProxyEnable"=dword:00000001
Change <your proxy IP address> to the private IP address of your HTTP Proxy, and <Proxy Port> to the port that iPrism is configured to proxy for (3128 by default). Save the file with the name you choose.
Copy setproxy.reg to login script folder.
Add the following line to the login script.
Regedit /s setproxy.reg
NOTE: To disable ProxyEnable"=dword:00000001 would be ProxyEnable"=dword:00000000