Hi,
HTTP Error 404.17 "The requested content appears to be script and will not be served by the static file handler."
The site sounds like it is not setup to handle .asmx extentions.
1. In IIS Manager click on your Website.
2. Under "Handler Mappings" find the association for the asmx extension.
3. If it is missing you can force inheritance from the parent site or server settings by clicking "Restore Inheritance".
Now, if you can see the mapping with the correct .net dll (verify the path to the right framework folder) the page should be correctly opened.
As well, what is your appPool configured as ? Classic or Integrated.
Cheers,
Hades6666