Also try an online scan through ESET:
http://www.eset.com/online-scannerThere's also a very useful utility called smitfraudfix that does a marvelous job of clearing out stuff like this. (Particularly if you also have a notice in the task bar telling you to install some antivirus)
http://siri.geekstogo.com/SmitfraudFix.phpAnd just for good measure, try to run gpedit.msc if it opens, navigate to User Configuration -> Administrative Templates -> System and check the status of the "Prevent access to registry editing tools" entry. If it's enabled, you can disable it to get use of regedit back. Also check under Logon/Logoff under System to see if Disable Task Manager has been enabled.
Also look at this option for getting safe mode boot back:
http://www.theeldergeek.com/add_safe_mode_to_boot_menu.htm