I downloaded CoLOS 4.2.1 from the Markem Imaje web site (the freeware version) and installed it. I found by building a sample label image file that its output is really just a couple of pages of XML tags, and is entirely in human readable format.
Since my application involves fixed layout, but variable information, the easiest solution is to parse the image file using a text editor like Notepad into variable fields and static text before and after each variable field. After entering new information into the variable fields, the static parts may be concatenated with the variable fields. The end result is an image file that may be sent to the printer over its USB port.
No printer driver was necessary for my purposes.
Brad