Question : Microsoft Word Error:  "This file could not be found."

Office 2007, updated with all Service Packs and patches.  All other file extensions open fine with exception of ".doc".  When opening a .doc file, (for example, "sample.doc"), I get error message that states "The command cannot be performed because a dialog box is open."  Click OK, and dialog box behind it states "The file could not be found. (C:\Documents.doc)".  Click OK and new box says: "This file could not be found.  (C:\Documents and Settings\...\and.doc)".  Click OK and new box says: "The directory name is not valid. (C:\Documents and Settings\...\sample.doc)."  Click OK and document finally opens.  

Can someone help resolve this issue?

Answer : Microsoft Word Error:  "This file could not be found."

My first thought is resetting the file association.  Right-click on the file, select "Open With" and select Microsoft Word.  At the bottom of the screen will be a box that says, "Always open with this...".  Ensure that check box is selected before opening the file.

If the path is getting altered (looked as if it was from your example) there may be something else intercepting the file... maybe a virus checker or, more likely, a plug-in within Word.  I would also look for any plug-ins and remove/disable them.