Another option is to download & run Process Explorer v12.04 to see which program has a particular file or directory open...and much more >>
http://technet.microsoft.com/en-gb/sysinternals/bb896653.aspxHere you'll find useful instructions for Process Explorer, with appropriate pictures>
http://ask-leo.com/how_do_i_find_out_what_program_is_using_all_my_cpu.html