http://forums.kayako.com/f84/how-setup-windows-2003-exchange-2003-smtp-relaying-14238/ 1. Log into Exchange 2003 server (192.168.5.25 in my example above) and start Exchange System Manager.
2. Expand the organization_name object, and then expand the Servers node. Expand the server_name object of the server on which you want to control mail relay, and then expand the Protocols node.
3. Expand the SMTP node, right-click the virtual SMTP server on which you want to control mail relay, and then click Properties
4. Click Relay.
5. In the Relay Restriction dialog box, several options are available. The Only the list below option is enabled by default; the list below this option is empty.
6. Click Add. Enter the IP address of the server running eSupport (192.168.5.80 in my example above).
7. In the Relay Restrictions dialog box, click OK.
8. Click Apply, and then click OK in the Default SMTP Virtual Server Properties dialog box.