To set a setting I use the following:
My.Settings.strHomeURL = txtHome.Text
(where strHomeURL is a type of String and has User scope and strHomeURL is the name of the setting)
To retrieve a setting from the same I use:
txtHome.Text = My.Settings.strHomeURL
(txtHome is a textbox)
You may also find the following helpful:
http://msdn.microsoft.com/en-us/library/cftf714c.aspx