MalwareBytes is designed to be run in normal mode, safe mode is not necessary.
For cleaning the system: MalwareBytes, ComboFix, HitmanPro, as well as ATF/TFC or CCleaner are good ones.
Plus other diagnostic tools to troubleshoot when problems persist.
For antivirus I use the FREE Avast, for anti-malware I'm using MalwareBytes with real-time protection.
I use Windows Firewall, and ensure that Windows and programs are fully updated.
I also use Spywareblaster which blocks activeX-based malware without wasting any resources.
I'm sure other users also have their own personal preference in AV and anti-malware.
If you like, check out these links below:
1. miekiemoes' "How to prevent Malware"
http://users.telenet.be/bluepatchy/miekiemoes/prevention.html 2. Simple and easy ways to keep your computer safe and secure on the Internet:
http://www.bleepingcomputer.com/tutorials/tutorial82.html 3. TonyKlein's article "So how did I get infected in the first place?"
http://www.spywareinfoforum.com/index.php?showtopic=60955
