for accessing OWA from outside the office, as you said need open the port 80 and 443 on router and point to your mail server. But if you got two mail server you can open the second one on different port and then for accessing to for example owa 2000 they use normal port but for owa 2003 they use 8080 and from your router you need to redirect 8080 to 80 and 8443 to 443.
It is very depend on your router settings. if this is the case if you give me the model I be able to help you more.