Humm... sounds like a malware trying to access USB port (maybe a autorun-style malware). I think you should do a full scan against viruses with a local and an online antivirus. After that, scan the Windows with SpyBot and remove possible malwares that can be found.
And then you can look at internals ways, with HijackThis and analyze each process. The Process Explorer and some USB monitor software can help you too. One process is accessing the USB port. Your job is to discover it. :)
Good antivirus - McAfee, Sophos, NOD32
Goood online antivirus - housecall.trendmicro.com
SpyBot -
www.safer-networking.orgHijackThis -
www.hijackthis.deProcess Explorer -
http://technet.microsoft.com/en-us/sysinternals/bb896653.aspxAdvanced USB Port Monitor -
www.aggsoft.com/usb-port-monitor.htmGood luck!